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Tuning a synthetic in vitro oscillator using control-theoretic tools
Abstract This paper demonstrates the effectiveness …
This paper demonstrates the effectiveness of sim- ple control-theoretic tools in generating simulation-guided ex- periments on a synthetic in vitro oscillator. A theoretical analysis of the behavior of such system is motivated by high cost, time consuming experiments, together with the excessive number of tuning parameters. A simplified model of the synthetic oscillator is chosen to capture only its essential features. The model is analyzed using the small gain theorem and the theory of describing functions. Such analysis reveals what are the parameters that primarily determine when the system can admit stable oscillations. Experimental verification of the theoretical and numerical findings is carried out and confirms the predicted results regarding the role of production and degradation rates.
role of production and degradation rates.  +
Authors Christopher Sturk, Elisa Franco, Richard M Murray  +
ID 2010c  +
Source Conference on Decision and Control (CDC), 2010 (Submitted)  +
Tag sfm10-cdc  +
Title Tuning a synthetic in vitro oscillator using control-theoretic tools +
Type Preprint  +
Categories Papers
Modification date
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15 May 2016 06:16:21  +
URL
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http://www.cds.caltech.edu/~murray/preprints/sfm10-cdc_s.pdf  +
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Tuning a synthetic in vitro oscillator using control-theoretic tools + Title
 

 

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