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Temperature Dependence of Biomolecular Circuit Designs
Abstract Quantifying performance of biomolecular ci …
Quantifying performance of biomolecular circuit designs across different environmental conditions is a key step in assessing their robustness. It is generally unclear how robust this performance is to the important environmental variable of temperature. Here, we address this issue for a transcriptional negative feedback circuit design that can speed up the response time using a combination of simple computational methods and dynamic experimental measurements. We use a simple two-state model of gene expression to illustrate different ways in which temperature dependence of reaction rate parameters can propagate through to the functional output. Next, we extend this analysis to the response time of a transcriptional negative feedback circuit design. Finally, we present experimental results characterizing how response time of a negative transcriptional feedback circuit depends on temperature. These results help to develop framework for assessing how functional output of biomolecular circuit designs depend on temperature.
lar circuit designs depend on temperature.  +
Authors Shaunak Sen and Richard M. Murray  +
ID 2013b  +
Source Submitted, 2013 Conference on Decison and Control (CDC)  +
Tag sm13-cdc  +
Title Temperature Dependence of Biomolecular Circuit Designs +
Type Conference Paper  +
Categories Papers
Modification date
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15 May 2016 06:15:26  +
URL
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http://www.cds.caltech.edu/~murray/preprints/sm13-cdc_s.pdf  +
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Temperature Dependence of Biomolecular Circuit Designs + Title
 

 

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