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A geometric and structural approach to the analysis and design of biological circuit dynamics: a theory tailored for synthetic biology
Abstract Much of the progress in developing our abi
Much of the progress in developing our ability to successfully design genetic circuits with predictable dynamics has followed the strategy of molding biological systems to fit into conceptual frameworks used in other disciplines, most notably the engineering sciences. Because biological systems have fundamental differences from systems in these other disciplines, this approach is challenging and the insights obtained from such analyses are often not framed in a biologically-intuitive way. Here, we present a new theoretical framework for analyzing the dynamics of genetic circuits that is tailored towards the unique properties associated with biological systems and experiments. Our framework approximates a complex circuit as a set of simpler circuits, which the system can transition between by saturating its various internal components. These approximations are connected to the intrinsic structure of the system, so this representation allows the analysis of dynamics which emerge solely from the system’s structure. Using our framework, we analyze the presence of structural bistability in a leaky autoactivation motif and the presence of structural oscillations in the Repressilator.
uctural oscillations in the Repressilator.  +
Authors John P. Marken, Fangzhou Xiao, Richard M. Murray  +
Funding Robust Multi-Layer Control Systems for Cooperative Cellular Behaviors +
ID 2019i  +
Source 2020 Winter q-bio  +
Tag mxm20-wqbio  +
Title A geometric and structural approach to the analysis and design of biological circuit dynamics: a theory tailored for synthetic biology +
Type Conference paper  +
Categories Papers
Modification date
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26 May 2020 15:56:37  +
URL
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https://www.biorxiv.org/content/10.1101/2020.02.18.953620v1  +
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A geometric and structural approach to the analysis and design of biological circuit dynamics: a theory tailored for synthetic biology + Title
 

 

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