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A State-space Realization Approach to Set Identification of Biochemical Kinetic Parameters |
Abstract |
This paper proposes a set-based parameter … This paper proposes a set-based parameter identi- fication method for biochemical systems. The developed method identifies not a single parameter but a set of parameters that all explains time-series experimental data, enabling the systematic characterization of the uncertainty of identified parameters. Our key idea is to use a state-space realization that has the same input-output behavior as experimental data instead of the experimental data itself for the identification. This allows us to relax the originally nonlinear identification problem to an LMI feasibility problem validating the norm bound of an error system. We show that regions of parameters can be efficiently classified into consistent and inconsistent parameter sets by combining the LMI feasibility problems and a generalized bisection algorithm. ems and a generalized bisection algorithm. +
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Authors | Yutaka Hori and Richard M. Murray + |
Funding | Biomolecular Breadboards for Prototyping and Debugging Synthetic Biocircuits + |
ID | 2014k + |
Source | 2015 European Control Conference (ECC) + |
Tag | hm15-ecc + |
Title | A State-space Realization Approach to Set Identification of Biochemical Kinetic Parameters + |
Type | Conference Paper + |
Categories | Papers |
Modification date This property is a special property in this wiki.
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15 May 2016 06:14:39 + |
URL This property is a special property in this wiki.
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http://www.cds.caltech.edu/~murray/preprints/hm15-ecc.pdf + |
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A State-space Realization Approach to Set Identification of Biochemical Kinetic Parameters + | Title |
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