Difference between revisions of "Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli"

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Latest revision as of 05:35, 26 May 2020

Title Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli
Authors Michaëlle N. Mayalu, Richard M. Murray
Source 2020 Winter q-bio
Abstract We have developed a mathematical framework to analyze the cooperative control of cell population homeostasis via paradoxical signaling in synthetic contexts. Paradoxical signaling functions through quorum sensing (where cells produce and release a chemical signal as a function of cell density). Precisely, the same quorum sensing signal provides both positive (proliferation) and negative (death) feedback in different signal concentration regimes. As a consequence, the relationship between intercellular quorum sensing signal concentration and net growth rate (cell proliferation minus death rates) can be non-monotonic. This relationship is a condition for robustness to certain cell mutational overgrowths and allows for increased stability in the presence of environmental perturbations. Here, we explore stability and robustness of a conceptualized synthetic circuit. Furthermore, we asses possible design principles that could exist among a subset of paradoxical circuit implementations. This analysis sparks the development a bio-molecular control theory to identify ideal underlying characteristics for paradoxical signaling control systems.
Type Conference paper
URL https://www.biorxiv.org/content/10.1101/2020.01.27.921734v1
Tag mm20-wqbio
ID 2019i
Funding DARPA BioCon
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