Browse wiki
From MurrayWiki
Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli |
Abstract |
We have developed a mathematical framework … We have developed a mathematical framework to analyze the cooperative control of cell population homeostasis via paradoxical signaling in synthetic contexts. Paradoxical signaling functions through quorum sensing (where cells produce and release a chemical signal as a function of cell density). Precisely, the same quorum sensing signal provides both positive (proliferation) and negative (death) feedback in different signal concentration regimes. As a consequence, the relationship between intercellular quorum sensing signal concentration and net growth rate (cell proliferation minus death rates) can be non-monotonic. This relationship is a condition for robustness to certain cell mutational overgrowths and allows for increased stability in the presence of environmental perturbations. Here, we explore stability and robustness of a conceptualized synthetic circuit. Furthermore, we asses possible design principles that could exist among a subset of paradoxical circuit implementations. This analysis sparks the development a bio-molecular control theory to identify ideal underlying characteristics for paradoxical signaling control systems. for paradoxical signaling control systems. +
|
---|---|
Authors | Michaëlle N. Mayalu, Richard M. Murray + |
Funding | Robust Multi-Layer Control Systems for Cooperative Cellular Behaviors + |
ID | 2019i + |
Source | 2020 Winter q-bio + |
Tag | mm20-wqbio + |
Title | Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli + |
Type | Conference paper + |
Categories | Papers |
Modification date This property is a special property in this wiki.
|
26 May 2020 05:35:06 + |
URL This property is a special property in this wiki.
|
https://www.biorxiv.org/content/10.1101/2020.01.27.921734v1 + |
hide properties that link here |
Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli + | Title |
---|