Browse wiki

From MurrayWiki
Jump to: navigation, search
Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli
Abstract We have developed a mathematical framework
We have developed a mathematical framework to analyze the cooperative control of cell population homeostasis via paradoxical signaling in synthetic contexts. Paradoxical signaling functions through quorum sensing (where cells produce and release a chemical signal as a function of cell density). Precisely, the same quorum sensing signal provides both positive (proliferation) and negative (death) feedback in different signal concentration regimes. As a consequence, the relationship between intercellular quorum sensing signal concentration and net growth rate (cell proliferation minus death rates) can be non-monotonic. This relationship is a condition for robustness to certain cell mutational overgrowths and allows for increased stability in the presence of environmental perturbations. Here, we explore stability and robustness of a conceptualized synthetic circuit. Furthermore, we asses possible design principles that could exist among a subset of paradoxical circuit implementations. This analysis sparks the development a bio-molecular control theory to identify ideal underlying characteristics for paradoxical signaling control systems.
for paradoxical signaling control systems.  +
Authors Michaëlle N. Mayalu, Richard M. Murray  +
Funding Robust Multi-Layer Control Systems for Cooperative Cellular Behaviors +
ID 2019i  +
Source 2020 Winter q-bio  +
Tag mm20-wqbio  +
Title Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli +
Type Conference paper  +
Categories Papers
Modification date
This property is a special property in this wiki.
26 May 2020 05:35:06  +
URL
This property is a special property in this wiki.
https://www.biorxiv.org/content/10.1101/2020.01.27.921734v1  +
hide properties that link here 
Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli + Title
 

 

Enter the name of the page to start browsing from.