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Quantifying Resource Competition and its Effects in the TX-TL System |
Abstract |
Without accounting for the limited availab … Without accounting for the limited availability of shared cellular resources, the standard model of gene expression fails to reliably predict experimental data obtained in vitro. To overcome this limitation, we develop a dynamical model of gene expression explicitly modeling competition for scarce resources. In addition to accurately describing the experimental data, this model only depends on a handful of easily identifiable parame- ters with clear physical interpretation. Based on this model, we then characterize the combinations of protein concentrations that are simultaneously realizable with shared resources. As application examples, we demonstrate how the results can be used to explain similarities/differences among different in vitro extracts, furthermore, we illustrate that accounting for resource usage is essential in circuit design considering the toggle switch. cuit design considering the toggle switch. +
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Authors | Andras Gyorgy and Richard M. Murray + |
Funding | Biomolecular Breadboards for Prototyping and Debugging Synthetic Biocircuits + |
ID | 2016k + |
Source | 2016 Conference on Decision and Control (CDC) + |
Tag | gm16-cdc + |
Title | Quantifying Resource Competition and its Effects in the TX-TL System + |
Type | Conference paper + |
Categories | Papers |
Modification date This property is a special property in this wiki.
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17 October 2016 15:59:46 + |
URL This property is a special property in this wiki.
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http://www.cds.caltech.edu/~murray/preprints/gm16-cdc.pdf + |
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Quantifying Resource Competition and its Effects in the TX-TL System + | Title |
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