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An In Silico Modeling Toolbox for Rapid Prototyping of Circuits in a Biomolecular “Breadboard” System |
Abstract |
In this paper, we develop an experimentall … In this paper, we develop an experimentally val- idated MATLAB software toolbox as an accompaniment to an in vitro cell-free biomolecular “breadboard” system. The toolbox gives insight into the dynamics of unmeasured states in the cell-free system, accounting especially for the resource usage. Parameter lumping and the reduced order modeling are used to maintain computational tractability and to avoid ill-conditioning. The toolbox allows for most applications to be implemented with standard set of commands for ease of use. Due to the breadboarding nature of the underlying cell-free sys- tem, the toolbox provides a general framework for experiment planning and predictive modeling for synthetic biomolecular circuits cell-free systems, accelerating our capacity to rationally design circuits from well characterized parts. gn circuits from well characterized parts. +
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Authors | Zoltan A. Tuza, Vipul Singhal, Jongmin Kim, Richard M. Murray + |
ID | 2013b + |
Source | 2013 Conference on Decision and Control (CDC) + |
Tag | tskm13-cdc + |
Title | An In Silico Modeling Toolbox for Rapid Prototyping of Circuits in a Biomolecular “Breadboard” System + |
Type | Conference paper + |
Categories | Papers |
Modification date This property is a special property in this wiki.
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25 September 2017 03:13:30 + |
URL This property is a special property in this wiki.
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http://www.cds.caltech.edu/~murray/preprints/tskm13-cdc_s.pdf + |
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An In Silico Modeling Toolbox for Rapid Prototyping of Circuits in a Biomolecular “Breadboard” System + | Title |
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