Browse wiki

From MurrayWiki
Jump to: navigation, search
Role of interaction network topology in controlling microbial population in consortia
Abstract Engineering microbial consortia is an impo …
Engineering microbial consortia is an important new frontier for synthetic biology given its efficiency in performing complex tasks and endurance to environmental uncertainty. Most synthetic circuits regulate population level behaviors via cell-to-cell communications, which are affected by spatially heterogeneous environments. Therefore, it is important to understand the limits on controlling system dynamics that are determined by interconnections among cell agents and provide a control strategy for engineering consortia. Here, we build a network model for a fractional population control circuit in two-strain consortia, and characterize the cell-to-cell communication network by topological properties, such as symmetry, locality and connectivity. Using linear network control theory, we relate the network topology to system output tracking performance. We analytically and numerically demonstrate that the minimum network control energy for accurate tracking depends on locality difference between two cell populations and how strongly the controller node contributes to communication strength. To realize robust consortia, we can manipulate the communication network topology and construct strongly connected consortia by altering chemicals in environments. Our results ground the expected cell population dynamics in its spatially organized communication network, and inspire directions in cooperative control in microbial consortia.
ooperative control in microbial consortia.  +
Authors Xinying Ren, Richard M Murray  +
Funding Robust Multi-Layer Control Systems for Cooperative Cellular Behaviors +
ID 2018b  +
Source To appear, 2018 Conference on Decision and Control (CDC)  +
Tag rm18-cdc  +
Title Role of interaction network topology in controlling microbial population in consortia +
Type Conference paper  +
Categories Papers
Modification date
This property is a special property in this wiki.
27 December 2018 05:39:02  +
This property is a special property in this wiki.  +
show properties that link here 


Enter the name of the page to start browsing from.