SURF 2012: Effects of circuit "layout" on circuit dynamics

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The idea here would be to understand how different design choices (eg, location and direction of genes on a plasmid) affect the dynamics of a circuit. The circuit that we test could be a genetic switch, repressilator, incoherent feedforward loop, etc. We could do both simulation and experiments (plus comparisons). This would likely involve cloning, measuring using flow cytometer and/or microscope, modeling using stochastic simulation and (possibly) differential equations. More to do here than one person can do, so lots of possibilities.