Networked Feedback Systems in Biology

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This is a joint project with John Doyle, funded by the ARO Institute for Collaborative Biotechnology. This page primarily describes the work done in Richard Murray's group.

Current participants:

Previous participants:


We are developing a theoretical foundation for a network science relevant to the understanding and design of complex "systems of systems" typified by biological networks. We are particularly focusing on the organizational principles underlying their ``robust yet fragile aspects, scalability, and evolvability, and demonstrating progress with case studies of varying detail using familiar and concrete examples from biological networks and network-centric technologies. Biological examples will focus on intracellular regulatory networks and intercellular communication.


  • E. Franco, P. O. Forsberg and R. M. Murray. "Design, modeling and synthesis of an in vitro transcription rate regulatory circuit" Submitted to American Control Conference 2008.
  • M. J. Dunlop, E. Franco, R. M. Murray. "A Multi-Model Approach to Identification of Biosynthetic Pathways." In Proceedings of the 26th American Control Conference 2007.
  • J. Ugander, M. J. Dunlop, R. M. Murray. "Analysis of a Digital Clock for Molecular Computing." In Proceedings of the 26th American Control Conference 2007.