Enabling Technologies for Cell-Silicon Interfacing

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This project focuses on the challenges faced by traditional detection and diagnostic technologies including shelf-life, signal amplification and sensitivity, continuous monitoring and device lifetime, detection range, and matrix compatibility. Further, it provides the enabling technology to expand functionality in computation and biochemical response for mixed-mode sensing devices.

Current participants:

Additional participants:

  • Samuel Clamons (PhD student, BE)


Past participants:

  • Elin Larsson (Technician, BE)
  • John McManus (Alumni, BBE/ARL)



The general objective is to develop the fundamental technologies required for cell-CMOS interfacing by demonstrating a proof-of-concept, mixed-mode sensing device that can sense and transduce signals from a complex matrix. Specific objectives:

  1. Engineer and validate an arsenic-sensing circuit into Bacillus megaterium. (
  2. Fabricate the microfluidics necessary for the retention of biological sensors to the IC
  3. Develop the CMOSIC technology, integrate it with the biological sensors and demonstrate the proof-of-concept for a mixed-mode sensing device
  4. Expand the capability of CMOSIC and cell-based circuits to enable communication from silicon to the cell, enabling programmability of cell-based circuits from ICs.


None to date

  • Agency: Army Research Laboratory
  • Grant number:
  • Start date: 1 Jan 2019
  • End date: 30 Dec 2021
  • Support:
  • Reporting: Annual reports