Difference between revisions of "Enabling Technologies for Cell-Silicon Interfacing"

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Project description (typically about a paragraph)
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This project focuses on the challenges faced by traditional detection and diagnostic technologies including shelf-life, signal amplification and sensitivity, continuous monitoring and device lifetime, detection range, and matrix compatibility. Further, it provides the enabling technology to expand functionality in computation and biochemical response for mixed-mode sensing devices.
  
 
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=== Objectives ===
 
=== Objectives ===
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[[Image:arl19-hybrid.png|right|400px]]
Description of the main objectives of the project
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The general objective is to develop the fundamental technologies required for cell-CMOS interfacing by demonstrating a proof-of-concept, mixed-mode sensing device that can
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sense and transduce signals from a complex matrix.  Specific objectives:
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# Engineer and validate an arsenic-sensing circuit into Bacillus megaterium. (
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# Fabricate the microfluidics necessary for the retention of biological sensors to the IC
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# Develop the CMOSIC technology, integrate it with the biological sensors and demonstrate the proof-of-concept for a mixed-mode sensing device
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# Expand the capability of CMOSIC and cell-based circuits to enable communication from silicon to the cell, enabling programmability of cell-based circuits from ICs.
  
 
=== References ===
 
=== References ===
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{{Project
 
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|Title=Enabling Technologies for Cell-Silicon Interfacing
 
|Title=Enabling Technologies for Cell-Silicon Interfacing

Revision as of 22:54, 25 December 2018

This project focuses on the challenges faced by traditional detection and diagnostic technologies including shelf-life, signal amplification and sensitivity, continuous monitoring and device lifetime, detection range, and matrix compatibility. Further, it provides the enabling technology to expand functionality in computation and biochemical response for mixed-mode sensing devices.

Current participants:

  • Elin Larsson (Technician, BE)

Additional participants:

  • Samuel Clamons (PhD student, BE)

Collaborators:

Past participants:

  • John McManus (Alumni, BBE/ARL)

Objectives

Arl19-hybrid.png

The general objective is to develop the fundamental technologies required for cell-CMOS interfacing by demonstrating a proof-of-concept, mixed-mode sensing device that can sense and transduce signals from a complex matrix. Specific objectives:

  1. Engineer and validate an arsenic-sensing circuit into Bacillus megaterium. (
  2. Fabricate the microfluidics necessary for the retention of biological sensors to the IC
  3. Develop the CMOSIC technology, integrate it with the biological sensors and demonstrate the proof-of-concept for a mixed-mode sensing device
  4. Expand the capability of CMOSIC and cell-based circuits to enable communication from silicon to the cell, enabling programmability of cell-based circuits from ICs.

References

None to date


  • Agency: Army Research Laboratory
  • Grant number:
  • Start date: 1 Jan 2019
  • End date: 30 Dec 2021
  • Support:
  • Reporting: Annual reports