Enabling Technologies for Cell-Silicon Interfacing
This project focuses on the challenges faced by traditional detection and diagnostic technologies including shelf-life, signal amplification and sensitivity, continuous monitoring and device lifetime, detection range, and matrix compatibility. Further, it provides the enabling technology to expand functionality in computation and biochemical response for mixed-mode sensing devices.
The general objective is to develop the fundamental technologies required for cell-CMOS interfacing by demonstrating a proof-of-concept, mixed-mode sensing device that can sense and transduce signals from a complex matrix. Specific objectives:
- Engineer and validate an arsenic-sensing circuit into Bacillus megaterium.
- Fabricate the microfluidics necessary for the retention of biological sensors to the IC
- Develop the CMOSIC technology, integrate it with the biological sensors and demonstrate the proof-of-concept for a mixed-mode sensing device
- Expand the capability of CMOSIC and cell-based circuits to enable communication from silicon to the cell, enabling programmability of cell-based circuits from ICs.
None to date