CDS 270-4, 2010: Bio-Control

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Spring 2010


NOTE: The Friday lectures will include discussing a paper related to the week topic. Papers will be announced about a week prior to the discussion.


Course Schedule

Week Date Lecture Topic Additional Material Journal Club
1 Introduction, Modeling biological systems
29 March (M) Course overview and objectives, layers of control of gene expression. Slides Syllabus
2 April (F) Modeling: Ordinary Differential Equations. Slides Suggested papers: Review on modeling genetic regulatory networks and Modeling the trp operon Model-based redesign of transcriptional networks
2 Building and analyzing models
6 April (T) Review of CDS methods for stability and periodic behaviors. Suggested papers: Angeli et al.
9 April (F) Modeling: Stochastic methods, Gillespie algorithm. Suggested papers: Gillespie's fundamental paper BioControl Reading: Defining bifurcations in stochastic systems

Course Administration

This course is a special topics course in which the lecture material has been prepared by a senior graduate student. The class is P/F only and there is no required homework and no midterm or final exam. Students will be required to work on an individual or team course project.

Course Project

Project proposals are due at 5pm on the last day of the Midterm examination period (May 4) and are due by 5pm on the last day of the final examination period (June 7). Project theme: select a cellular regulatory mechanism, define a list of important features of the system, come up with a modeling framework and carry out an analysis of its properties (e.g. stability, robustness, modularity...).