Difference between revisions of "CDS 270-4, 2010: Bio-Control"

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(Course Schedule)
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| Modeling: Ordinary Differential Equations. [[Media:CDS270-4-2010-Week1-2.pdf | Slides]]  
 
| Modeling: Ordinary Differential Equations. [[Media:CDS270-4-2010-Week1-2.pdf | Slides]]  
 
| Papers: [http://www.pnas.org/content/98/4/1364.full Modeling the trp operon] and [http://nar.oxfordjournals.org/cgi/content/short/37/5/e38  Model-based redesign of transcriptional networks]
 
| Papers: [http://www.pnas.org/content/98/4/1364.full Modeling the trp operon] and [http://nar.oxfordjournals.org/cgi/content/short/37/5/e38  Model-based redesign of transcriptional networks]
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| colspan=3 | '''Building and analyzing models'''
 
| colspan=3 | '''Building and analyzing models'''
 
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Revision as of 00:08, 3 April 2010

CaltechLogoPrimaryOrangeCropped.gif Bio-Control Cdslogo.png
Spring 2010


NOTE: The Friday lectures will include discussing a paper related to the week topic. Papers will be announced about a week prior to the discussion.


Course Schedule

Week Date Lecture Topic Additional Material
1 Introduction, Modeling biological systems
29 March (M) Course overview and objectives, layers of control of gene expression. Slides Syllabus
2 April (F) Modeling: Ordinary Differential Equations. Slides Papers: Modeling the trp operon and Model-based redesign of transcriptional networks
Building and analyzing models
6 April (T) Review of CDS methods for stability and periodic behaviors. [[ | Slides]] [Angeli et al. ]
9 April (F) Modeling: Stochastic methods, Gillespie algorithm. [[ | Slides]] [[ Papers: Gillespie's fundamental paper [Journal Club: TBD] ]]

Course Administration

This course is a special topics course in which much of the lecture material has been prepared by a senior graduate student. The class is P/F only and there is no required homework and no midterm or final exam. Students will be required to work on an individual or team course project.

Course Project

Project proposals are due at 5pm on the last day of the Midterm examination period (May 4) and are due by 5pm on the last day of the final examination period (June 7). Project theme: select a cellular regulatory mechanism, define a list of important features of the system, come up with a modeling framework and carry out an analysis of its properties (e.g. stability, robustness, modularity...).