Difference between revisions of "A stochastic framework for the design of transient and steady state behavior of biochemical reaction networks"

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| authors = Ania A. Baetica, Ye Yuan, Jorge Goncalves and Richard M. Murray
 
| authors = Ania A. Baetica, Ye Yuan, Jorge Goncalves and Richard M. Murray
 
| title = A stochastic framework for the design of transient and steady state behavior of biochemical reaction networks
 
| title = A stochastic framework for the design of transient and steady state behavior of biochemical reaction networks
| source = Submitted, 2015 Conference on Decision and Control (CDC)
+
| source = 2015 Conference on Decision and Control (CDC)
 
| year = 2015
 
| year = 2015
 
| type = Conference Paper
 
| type = Conference Paper

Latest revision as of 16:32, 3 September 2019


Ania A. Baetica, Ye Yuan, Jorge Goncalves and Richard M. Murray
2015 Conference on Decision and Control (CDC)

Stochasticity plays an essential role in biochemical systems. Stochastic behaviors of bimodality, excitability, and fluctuations have been observed in biochemical reaction networks at low molecular numbers. Stochastic dynamics can be captured by modeling the system using a forward Kolmogorov equation known in the biochemical literature as the chemical master equation. The chemical master equation describes the time evolution of the probability distributions of the molecule species. We develop a stochastic framework for the design of these time evolving probability distributions that includes specifying their uni-/multi-modality, their first moments, and their rate of convergence to the stationary distribution. By solving the corresponding optimizations programs, we determine the reaction rates of the biochemical systems that satisfy our design specifications. We then apply the design framework to examples of biochemical reaction networks to illustrate its strengths and limitations.