Design of insulating devices for in vitro synthetic circuits

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Elisa Franco, Domitilla Del Del Vecchio, Richard M Murray
Conference on Decision and Control (CDC), 2009 (Submitted)

This paper describes a synthetic in vitro genetic circuit programmed to work as an insulating device. This circuit is composed of nucleic acids, which can be designed to interact according to user defined rules, and of few proteins that perform catalytic functions. A model of the circuit is derived from first principle biochemical laws. This model is shown to exhibit time-scale separation that makes its output insensitive to downstream time varying loads. Simulation results show the circuit effectiveness and represent the starting point for future experimental testing of the device.