Supplement: Biomolecular Feedback Systems
Domitilla Del Vecchio (U. Mich) and Richard M. Murray (Caltech)
Biological systems make use of feedback in an extraordinary number of ways, on scales ranging from molecules to cells to organisms to ecosystems. This page collects information on the analysis of feedback systems in biology. What is currently connected here are working notes on the supplement and links to further information. This information is in progress; comments and constructive suggestions are welcome and can be sent to Richard Murray.
Cell Biology (Del Vecchio and Murray)
The text contains a number of examples and exercises related to some of the molecular mechanisms for feedback within cells. These examples are being expanded into a set of notes by Domitilla Del Vecchio and Richard Murray based on a variety of presentations, lectures and notes.
Some of the examples for this material will be pulled from tutorial presentations on control given at systems biology workshops:
- Tutorial on control theory, IMA workshop on Design Principles in Biological Systems, 21 April 2008.
Summarize work of Full, Holmes et al showing role of dynamics and feedback in insect locomotion.
- Low order models to describe locomotion
- Bifurcations of stable gates, neural pattern generator
- The Dynamics of Legged Locomotion: Models, Analyses, and Challenges, Philip Holmes, Robert J. Full, Dan Koditschek, John Guckenheimer. SIAM Review, 48(2):207-304, 2006. (requires subscription)
Summarize work of Dickinson, Srinivasan et al showing mechanisms for visual sensoring processing and sensor fusion in insect flight.
Motor Control Systems
Summarize work on Massaquoi from CSHL course.