April 22, 2002. Hamid Bolouri, Modeling genetic regulatory networks
Abstract
Aside from asymmetries in the egg, all
animal development and evolution must be encoded in DNA. Since animals mostly
share the same protein families, differences among species must be due to
differential regulation of genes. The primary means of controlling location,
timing, and level of gene activity is transcriptional. This means models of
genetic regulatory networks can be fully experimentally tested by
identification of predicted transcription factor binding sites and in-situ
hybridization of reporter constructs; two well-established technologies.
I will describe some approaches to modeling genetic regulatory networks and
discuss some challenges ahead.
Reading Material. See science article, 'A Genomic Regulatory Network for Development':