<?xml version="1.0" encoding="UTF-8"?>
<!-- Created by XMLPrettyPrinter on 1/11/2003 -->
<sbml xmlns = "http://www.sbml.org/sbml/level1" level = "1" version = "1" xmlns:jd = "http://www.sys-bio.org/sbml">
   <annotations>
      <jd:header>
         <VersionHeader SBMLVersion = "1.0"/>
         <ModelHeader Author = "Mr Unknown" ModelVersion = "0.0" ModelTitle = "No Title"/>
      </jd:header>
      <jd:display>
         <SBMLGraphicsHeader BackGroundColor = "15728639"/>
      </jd:display>
      <jd:otherDisplayObjects>
         <textObject name = "Linear Pathway with negative feedback from S4 to first step, displays oscillations">
            <font fontName = "Arial" fontSize = "10" fontStyle = "B" fontColor = "0"/>
            <boundingBox x = "19" y = "15" w = "512" h = "16"/>
         </textObject>
      </jd:otherDisplayObjects>
   </annotations>
   <!--                     -->
   <!--  Model Starts Here  -->
   <!--                     -->
   <model name = "untitled">
      <annotations>
      </annotations>
      <listOfCompartments>
         <compartment name = "uVol" volume = "1">
            <annotations>
               <jd:display>
                  <boundingBox x = "0" y = "0" w = "0" h = "0"/>
               </jd:display>
            </annotations>
         </compartment>
      </listOfCompartments>
      <listOfSpecies>
         <specie name = "S1" boundaryCondition = "false" initialAmount = "0" compartment = "uVol">
            <annotations>
               <jd:display x = "138" y = "104" iconIndex = "-1" edgeThickness = "1"
                           edgeColor = "0" selectedEdgeColor = "255" fillColor = "15728639" borderType = "ntRound">
                  <font fontName = "Arial" fontSize = "8" fontStyle = "" fontColor = "0"/>
               </jd:display>
            </annotations>
         </specie>
         <specie name = "S2" boundaryCondition = "false" initialAmount = "0" compartment = "uVol">
            <annotations>
               <jd:display x = "234" y = "143" iconIndex = "-1" edgeThickness = "1"
                           edgeColor = "0" selectedEdgeColor = "255" fillColor = "15728639" borderType = "ntRound">
                  <font fontName = "Arial" fontSize = "8" fontStyle = "" fontColor = "0"/>
               </jd:display>
            </annotations>
         </specie>
         <specie name = "S3" boundaryCondition = "false" initialAmount = "0" compartment = "uVol">
            <annotations>
               <jd:display x = "318" y = "178" iconIndex = "-1" edgeThickness = "1"
                           edgeColor = "0" selectedEdgeColor = "255" fillColor = "15728639" borderType = "ntRound">
                  <font fontName = "Arial" fontSize = "8" fontStyle = "" fontColor = "0"/>
               </jd:display>
            </annotations>
         </specie>
         <specie name = "S4" boundaryCondition = "false" initialAmount = "0" compartment = "uVol">
            <annotations>
               <jd:display x = "413" y = "207" iconIndex = "-1" edgeThickness = "1"
                           edgeColor = "0" selectedEdgeColor = "255" fillColor = "15728639" borderType = "ntRound">
                  <font fontName = "Arial" fontSize = "8" fontStyle = "" fontColor = "0"/>
               </jd:display>
            </annotations>
         </specie>
         <specie name = "X0" boundaryCondition = "true" initialAmount = "10" compartment = "uVol">
            <annotations>
               <jd:display x = "33" y = "60" iconIndex = "-1" edgeThickness = "2"
                           edgeColor = "0" selectedEdgeColor = "255" fillColor = "15728639" borderType = "ntRound">
                  <font fontName = "Arial" fontSize = "8" fontStyle = "" fontColor = "0"/>
               </jd:display>
            </annotations>
         </specie>
         <specie name = "X1" boundaryCondition = "true" initialAmount = "0" compartment = "uVol">
            <annotations>
               <jd:display x = "415" y = "292" iconIndex = "-1" edgeThickness = "2"
                           edgeColor = "0" selectedEdgeColor = "255" fillColor = "15728639" borderType = "ntRound">
                  <font fontName = "Arial" fontSize = "8" fontStyle = "" fontColor = "0"/>
               </jd:display>
            </annotations>
         </specie>
      </listOfSpecies>
      <listOfReactions>
         <reaction name = "J0" reversible = "false">
            <listOfReactants>
               <specieReference specie = "X0" stoichiometry = "1"/>
            </listOfReactants>
            <listOfProducts>
               <specieReference specie = "S1" stoichiometry = "1"/>
            </listOfProducts>
            <annotations>
               <jd:arcSeg lineThickness = "1" lineColor = "6587523" fillColor = "6587523" selectedLineColor = "255">
                  <pt x = "90" y = "88"/>
                  <pt x = "91" y = "89"/>
                  <pt x = "91" y = "89"/>
               </jd:arcSeg>
            </annotations>
            <kineticLaw formula = "VM1*(X0-S1/Keq1)/(1+X0+S1+S4^h)">
               <listOfParameters>
                  <parameter name = "VM1" value = "10"/>
                  <parameter name = "Keq1" value = "10"/>
                  <parameter name = "h" value = "10"/>
               </listOfParameters>
            </kineticLaw>
         </reaction>
         <reaction name = "J1" reversible = "false">
            <listOfReactants>
               <specieReference specie = "S1" stoichiometry = "1"/>
            </listOfReactants>
            <listOfProducts>
               <specieReference specie = "S2" stoichiometry = "1"/>
            </listOfProducts>
            <annotations>
               <jd:arcSeg lineThickness = "1" lineColor = "6587523" fillColor = "6587523" selectedLineColor = "255">
                  <pt x = "191" y = "129"/>
                  <pt x = "192" y = "130"/>
                  <pt x = "192" y = "130"/>
               </jd:arcSeg>
            </annotations>
            <kineticLaw formula = "(10*S1-2*S2)/(1+S1+S2)">
            </kineticLaw>
         </reaction>
         <reaction name = "J2" reversible = "false">
            <listOfReactants>
               <specieReference specie = "S2" stoichiometry = "1"/>
            </listOfReactants>
            <listOfProducts>
               <specieReference specie = "S3" stoichiometry = "1"/>
            </listOfProducts>
            <annotations>
               <jd:arcSeg lineThickness = "1" lineColor = "6587523" fillColor = "6587523" selectedLineColor = "255">
                  <pt x = "281" y = "166"/>
                  <pt x = "282" y = "167"/>
                  <pt x = "282" y = "167"/>
               </jd:arcSeg>
            </annotations>
            <kineticLaw formula = "(10*S2-2*S3)/(1+S2+S3)">
            </kineticLaw>
         </reaction>
         <reaction name = "J3" reversible = "false">
            <listOfReactants>
               <specieReference specie = "S3" stoichiometry = "1"/>
            </listOfReactants>
            <listOfProducts>
               <specieReference specie = "S4" stoichiometry = "1"/>
            </listOfProducts>
            <annotations>
               <jd:arcSeg lineThickness = "1" lineColor = "6587523" fillColor = "6587523" selectedLineColor = "255">
                  <pt x = "370" y = "198"/>
                  <pt x = "371" y = "199"/>
                  <pt x = "371" y = "199"/>
               </jd:arcSeg>
            </annotations>
            <kineticLaw formula = "(10*S3-2*S4)/(1+S3+S4)">
            </kineticLaw>
         </reaction>
         <reaction name = "J4" reversible = "false">
            <listOfReactants>
               <specieReference specie = "S4" stoichiometry = "1"/>
            </listOfReactants>
            <listOfProducts>
               <specieReference specie = "X1" stoichiometry = "1"/>
            </listOfProducts>
            <annotations>
               <jd:arcSeg lineThickness = "1" lineColor = "6587523" fillColor = "6587523" selectedLineColor = "255">
                  <pt x = "419" y = "255"/>
                  <pt x = "420" y = "256"/>
                  <pt x = "420" y = "256"/>
               </jd:arcSeg>
            </annotations>
            <kineticLaw formula = "V4*S4/(KS4+S4)">
               <listOfParameters>
                  <parameter name = "V4" value = "2.5"/>
                  <parameter name = "KS4" value = "0.5"/>
               </listOfParameters>
            </kineticLaw>
         </reaction>
      </listOfReactions>
   </model>
</sbml>
