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Cellular
Models
Model Repository
Other SBML repositories: ERATO
UPDATED (12-January-03)
NOTE: All the following models can be read by SBML Level 1 Compatible Simulation tools, eg Jarnac, Gepasi, JDesigner and Cellerator
Simple
Model Models
| Linear Model | |
| Branch Model | |
| Simple Cycle Model | |
| Two Cycle Model |
Real-World Models (These models can be rendered by JDesigner)
| Positive Feedback Oscillator | From Heinrich et al 1977 review on metabolic regulation |
| Single Gene Feedback Oscillator | From SBML Bioinfomatics Standards Paper |
| Negative Feedback in MAPK | From Boris Kholodenko, EJB, 267, 1588 (2000) |
| Calvin Cycle Model | From Mark Poolman (mgpoolman@brookes.ac.uk) and David Fell (http://mudshark.brookes.ac.uk) |
| Repressilator | This version from http://gene.genetics.uga.edu/~aleman/kinnew/ (Elowitz and Leibler (2000) Nature.403: 335 - 338) |
| Tyson6 Cell Cycle Model. | This was taken from the repository at Caltech (Maintained by Maria Schilstra) to illustrate how simple it was to read SBML files generated by Cellerator. (Modified for JDesigner display) Tyson JJ, (1991) . Modeling the cell division cycle: cdc2 and cyclin interactions. PNAS, 88: 7328-7332. |
Theoretical Models (These models can be rendered by JDesigner)
| Simple Negative Feedback Oscillator |
The Following Models were taken from the Gepasi site (with permission)
The following were taken from the Gepasi site at www.gepasi.org to illustrate the ease with which it is now possible to interchange models between different simulators. The SBML models at gepasi.org were loaded into JDesigner, and adjusted by hand so that the networks were more ordered on screen.
Taken from the Gepasi site with permission and modified for JDesigner display, see www.gepasi.org for details.
| Yeast Glycolysis. | From Pritchard and Kell (2002) Eur. J. Biochem. 269, 3894-3904 |
| Signal Transduction Cascade. | Further details in http://gepasi.dbs.aber.ac.uk/metab/signal/signal.html |
| Minimal chemical Hopf bifurcation | |
| The Henri-Michaelis-Menten model |
Documentation for sbml can be obtained from:
ERATO XMl Spec - Second Draft
Sample Script from Jarnac to generate SBML
Here is an example of the sort of script that can be used to generate SBML files:
// Declare the model, $Xn represent
boundary fixed species
// Lines starting with // are comments
p = defn SimpleExample
// Describe a three step linear
pathway
$X0 -> S1; k1*X0;
S1 -> S2; k2*S1;
S2 -> $X1; k3*S2;
end;
// Write out the xml file
p.xml ("simple.xml");
To read the SBML back in, one can use the script:
p = network ("simple.xml");