Cellular Models

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Model Repository

Other SBML repositories: ERATO

UPDATED (12-January-03)

NOTE: All the following models can be read by SBML Level 1 Compatible Simulation tools, eg Jarnac, Gepasi, JDesigner and Cellerator

 

Simple Model Models
 
Linear Model  
Branch Model
Simple Cycle Model  
Two Cycle Model  

 

Real-World Models (These models can be rendered by JDesigner)

Positive Feedback Oscillator From Heinrich et al 1977 review on metabolic regulation
Single Gene Feedback Oscillator From SBML Bioinfomatics Standards Paper
Negative Feedback in MAPK   From Boris Kholodenko, EJB, 267, 1588 (2000)
Calvin Cycle Model From Mark Poolman (mgpoolman@brookes.ac.uk) and David Fell (http://mudshark.brookes.ac.uk)
Repressilator This version from http://gene.genetics.uga.edu/~aleman/kinnew/ (Elowitz and Leibler (2000) Nature.403: 335 - 338)
Tyson6 Cell Cycle Model. This was taken from the repository at Caltech (Maintained by Maria Schilstra) to illustrate how simple it was to read SBML files generated by Cellerator.  (Modified for JDesigner display) Tyson JJ, (1991) . Modeling the cell division cycle: cdc2 and cyclin interactions. PNAS, 88: 7328-7332.
 

Theoretical Models (These models can be rendered by JDesigner)

Simple Negative Feedback Oscillator  

 

The Following Models were taken from the Gepasi site (with permission)

The following were taken from the Gepasi site at www.gepasi.org to illustrate the ease with which it is now possible to interchange models between different simulators. The SBML models at gepasi.org were loaded into JDesigner, and adjusted by hand so that the networks were more ordered on screen.

Taken from the Gepasi site with permission and modified for JDesigner display, see www.gepasi.org for details.

Yeast Glycolysis. From Pritchard and Kell (2002) Eur. J. Biochem. 269, 3894-3904
Signal Transduction Cascade. Further details in http://gepasi.dbs.aber.ac.uk/metab/signal/signal.html
Minimal chemical Hopf bifurcation  
The Henri-Michaelis-Menten model  
 

Documentation for sbml can be obtained from:

ERATO XMl Spec - Second Draft 


Sample Script from Jarnac to generate SBML

Here is an example of the sort of script that can be used to generate SBML files:

// Declare the model, $Xn represent boundary fixed species
// Lines starting with // are comments

p = defn SimpleExample

        // Describe a three step linear pathway
        $X0 -> S1;  k1*X0;
         S1 -> S2;  k2*S1;
         S2 -> $X1; k3*S2;
end;

// Write out the xml file
p.xml ("simple.xml");

To read the SBML back in, one can use the script:

p = network ("simple.xml");